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The Synthesis of Biologically Active Guanidines

Harper, Philip Mark (2016) The Synthesis of Biologically Active Guanidines. PhD thesis, Prifysgol Bangor University.

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Abstract

Abstract Several new alkyl (147, 161 and 167) and alkoxy-methyl derivatives (171, 175) were prepared as analogues of the anti-tumour agent tirapazamine (38). These were prepared in an attempt to couple them to the pro-drug delivery agent 52. The bicyclic guanidine natural product monalidine A (186) was prepared as its hydrochloride salt from 2-undecanone via a novel 3-step synthesis. The biological activity of monalidine A (186) and one of its synthetic precursors were evaluated against Leishmaniasis infantum and Trypanosoma cruzi. Research towards the total synthesis of the tricyclic arbusculidine A (187) from cucumber aldehyde is reported.

Item Type: Thesis (PhD)
Subjects: Degree Thesis
Departments: College of Physical and Applied Sciences > School of Chemistry
Degree Thesis
Date Deposited: 16 Nov 2016 09:05
Last Modified: 16 Nov 2016 09:05
URI: http://e.bangor.ac.uk/id/eprint/9760
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