Individualised exercise improves endothelial function in patients with rheumatoid arthritis

Metsios, G.S. and Stavropoulos-Kalinoglou, A. and Veldhuijzen van Zanten, J. and Nightingale, P. and Sandoo, A. and Dimitroulas, T. and Kitas, G.D. and Koutedakis, Y. (2013) Individualised exercise improves endothelial function in patients with rheumatoid arthritis. Annals of Rheumatic Diseases, 73 ((4)). pp. 748-751. DOI: 10.1136/annrheumdis-2013-203291

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We investigated the effects of individualised combined resistance and aerobic exercise on microvascular and macrovascular function in rheumatoid arthritis (RA) patients. Forty age-matched, gender-matched and body mass index (BMI)-matched patients were allocated to either an exercise group, receiving a 6 months tailored aerobic and resistance exercise intervention, or controls receiving only information about the benefits of exercise. Participants were assessed for microvascular (acetylcholine (Ach) and sodium nitroprusside (SNP)) and macrovascular (flow-mediated dilatation (FMD) and glyceryl trinitrate (GTN)) endothelial function, maximal oxygen uptake, disease activity and severity (C-reactive protein (CRP), disease activity score 28 and health assessment questionnaire). Data were collected at baseline, 3 months and at the end of the intervention (6 months). At baseline, demographic, anthropometric, disease-related characteristics and endothelial function parameters were similar between the exercise and control groups (p>0.05). Repeated measures analysis of variance revealed a significant improvement in endothelial function parameters at 3 (GTN: p<0.001) or 6 months (Ach: p=0.016, SNP: p=0.045, FMD: p=0.016) in the exercise but not in the control group. Generalised estimated equations detected that maximal oxygen uptake was a strong predictor for the observed changes in Ach (p=0.009) and GTN (p<0.001) whereas logCRP for SNP (p=0.017) and GTN (p=0.008). An exercise programme designed to meet individual needs and physical abilities significantly improves microvascular and macrovascular function in parallel with disease-related characteristics in RA patients. The potential long-term beneficial effects of such interventions at reducing cardiovascular risk in these patients merit further exploration

Item Type: Article
Subjects: Research Publications
Departments: College of Health and Behavioural Sciences > School of Sport, Health and Exercise Sciences
Date Deposited: 09 Dec 2014 16:41
Last Modified: 24 Sep 2015 02:15
ISSN: 1468-2060
URI: http://e.bangor.ac.uk/id/eprint/768
Identification Number: DOI: 10.1136/annrheumdis-2013-203291
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