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Nanopore test circuit for single-strand DNA sequencing

Palego, C. and Hwang, J.C.M. and Merla, C. and Apollonio, F. and Liberti, M. (2012) Nanopore test circuit for single-strand DNA sequencing. In: IEEE 12th Topical Meeting on Silicon Monolithic Integrated Circuits in RF Systems (SiRF), Santa Clara, USA, 16-18 Jan 2012.

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Abstract

A nanopore test circuit is proposed for single-strand DNA sequencing, which allows real-time sensing of the electric conductance of individual sections of a DNA strand as it is pulled through the nanopore by an electric current at a controlled speed. The test circuit is based on a planar microchamber with a nanochannel drilled through its multilayer graphene electrode by an electron beam. The nanochannel is self-aligned with a nanopore created in the lipid bilayer membrane of liposomes by nanosecond electric pulses. Simulation shows that by carefully controlling the magnitude, period, and repetition rate of the pulses, the diameter of the nanopore can be optimized for the best speed the DNA is pulled through the nanopore.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Subjects: Research Publications
Departments: College of Physical and Applied Sciences > School of Electronic Engineering
Date Deposited: 27 Jan 2016 03:36
Last Modified: 27 Jan 2016 03:36
URI: http://e.bangor.ac.uk/id/eprint/6159
Identification Number: DOI: 10.1109/SiRF.2012.6160154
Publisher: IEEE publishing
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