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Coplanar stripline microchamber for electrical detection of live and dead biological cells

Ning, Y. and Multari, C. and Luo, X. and Palego, C. and Molinero, D. and Cheng, X. and Hwang, J.C.M. and Merla, C. (2013) Coplanar stripline microchamber for electrical detection of live and dead biological cells. In: European Microwave Conference (EuMC), Nurember, October 2013.

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Abstract

An improved microchamber for electrical detection of biological cells was designed, fabricated and tested. The microchamber was formed between a gold coplanar stripline fabricated on a sapphire microscope slide and a single microfluidic channel fabricated in a polydimethylsiloxane cover. Compared with the previous design of a coplanar waveguide on a quartz slide with multiple microfluidic channels, the present microchamber was more sensitive, compact, rugged, and transparent. Tests on Jurkat cells in both time and frequency domains demonstrated single-cell sensing potential, as well as discrimination of live vs. dead cells. The test results could be explained by a simple equivalent-circuit model, which efficiently de-embedded the intrinsic cell properties from solution and electrode effects.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Subjects: Research Publications
Departments: College of Physical and Applied Sciences > School of Electronic Engineering
Date Deposited: 27 Jan 2016 03:36
Last Modified: 27 Jan 2016 03:36
URI: http://e.bangor.ac.uk/id/eprint/6155
Publisher: IEEE publishing
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