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Fast, compact and label-free electrical detection of live and dead single cells

Ning, Y. and Multari, C.R. and Luo, X. and Merla, C. and Palego, C. and Cheng, X and Hwang, J.C.M. (2013) Fast, compact and label-free electrical detection of live and dead single cells. In: Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO), 2013 IEEE MTT-S International, Singapore.

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Abstract

Using a novel broadband microchamber, electrical detection of live and dead single cells was demonstrated. Tests on Jurkat cells showed that live cells had lower resistance but higher capacitance than that of dead cells. The test results were compared with the limited literature on broadband electrical detection of single cells and the discrepancies, both qualitative and quantitative, were discussed. These results indicate that, while broadband electrical detection at the single-cell level is becoming feasible, many challenges remain in impedance match, calibration, sensitivity, cell manipulation, solution effect and modeling.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Subjects: Research Publications
Departments: College of Physical and Applied Sciences > School of Electronic Engineering
Date Deposited: 27 Jan 2016 03:36
Last Modified: 27 Jan 2016 03:36
URI: http://e.bangor.ac.uk/id/eprint/6154
Identification Number: DOI: 10.1109/IMWS-BIO.2013.6756250
Publisher: IEEE publishing
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