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Improved broadband electrical detection of individual biological cells

Ning, Y. and Ma, X. and Multari, C. and Luo, X. and Gholizadeb, V. and Palego, C. and Cheng, X. and Hwang, J. (2015) Improved broadband electrical detection of individual biological cells. In: IEEE International Microwave Symposium, Phoenix, USA, May 2015.

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Abstract

Based on a homemade probe station on top of an inverted microscope for simultaneous microwave measurement and visual validation, broadband detection of live Jurkat cells was successfully extended from 2-3.5 GHz to 0.5-20 GHz with comparable sensitivity and reproducibility. With a carefully optimized coplanar waveguide, closely spaced microwave probes, and frequent calibrations, reference planes were established next to the microfluidic channel, which resulted in smooth and well-behaved scattering parameters without spurious resonances. From the measured scattering parameters, the extracted cytoplasm resistance of 190 kΩ was consistent with the previously reported value but validated over a much wider bandwidth.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Subjects: Research Publications
Departments: College of Physical and Applied Sciences > School of Electronic Engineering
Date Deposited: 14 Jan 2016 03:53
Last Modified: 21 Jan 2016 03:15
URI: http://e.bangor.ac.uk/id/eprint/6086
Identification Number: DOI: 10.1109/MWSYM.2015.7166722
Publisher: IEEE publishing
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