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Symmetric Dimethylarginine Is Not Associated with Cumulative Inflammatory Load or Classical Cardiovascular Risk Factors in Rheumatoid Arthritis: A 6-Year Follow-Up Study

Dimitroulas, T. and Hodson, J. and Sandoo, A. and Smith, J.P. and Douglas, K.M. and Kitas, G.D. (2015) Symmetric Dimethylarginine Is Not Associated with Cumulative Inflammatory Load or Classical Cardiovascular Risk Factors in Rheumatoid Arthritis: A 6-Year Follow-Up Study. Mediators of Inflammation. ID 796562. DOI: 10.1155/2015/796562

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Abstract

Symmetric dimethylarginine (SDMA) indirectly inhibits nitric oxide (NO) synthesis and predicts cardiovascular and all-cause mortality in high-risk patients. The aim of our study was to investigate the associations of cumulative inflammatory burden (assessed by serial measurements of inflammatory markers) and classical cardiovascular (CV) disease risk factors with SDMA in RA patients. 201 RA patients (155 females, median age 67 (59�73)) were assessed at baseline (2006). Classical CV disease risk factors were recorded and systemic inflammation was determined by themeasurement of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). At follow-up (2012) SDMA levels were measured by enzyme-linked immunosorbent assay.Mean SDMA levels in RA population were 0.40 (0.40�0.53) ����mol/L. No significant association between SDMA and cumulative inflammatory load was established in the analysis. SDMA levels were not found to be significantly related to CV disease risk factors.We explored the potential relationship between SDMA and cumulative inflammatory burden in patients with RA and obtained negative results. SDMA did not relate to CV disease risk factors in our population and its clinical significance as a surrogate marker of endothelial dysfunction in patients with RA remains to be determined.

Item Type: Article
Subjects: Research Publications
Departments: College of Health and Behavioural Sciences > School of Sport, Health and Exercise Sciences
Date Deposited: 25 Nov 2015 03:18
Last Modified: 03 Dec 2015 11:16
ISSN: 0962-9351
URI: http://e.bangor.ac.uk/id/eprint/5904
Identification Number: DOI: 10.1155/2015/796562
Publisher: Hindawi Publishing Corporation
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