A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Sandoo, A. and Kitas, G.D. (2015) A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology. Journal of Visualized Experiments, 96. Article Number: e52339. DOI: doi:10.3791%2F52339

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The endothelium is the innermost lining of the vasculature and is involved in the maintenance of vascular homeostasis. Damage to the endothelium may predispose the vessel to atherosclerosis and increase the risk for cardiovascular disease. Assessments of peripheral endothelial function are good indicators of early abnormalities in the vascular wall and correlate well with assessments of coronary endothelial function. The present manuscript details the important methodological steps necessary for the assessment of microvascular endothelial function using laser Doppler imaging with iontophoresis, large vessel endothelial function using flow-mediated dilatation, and carotid atherosclerosis using carotid artery ultrasound. A discussion on the methodological considerations for each of the techniques is also presented, and recommendations are made for future research.

Item Type: Article
Subjects: Research Publications
Departments: College of Health and Behavioural Sciences > School of Sport, Health and Exercise Sciences
Date Deposited: 21 Nov 2015 03:28
Last Modified: 11 Dec 2015 03:25
ISSN: 1940-087X
URI: http://e.bangor.ac.uk/id/eprint/5885
Identification Number: DOI: doi:10.3791%2F52339
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