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Executive dysfunction predicts social cognition impairment in amyotrophic lateral sclerosis

Watermeyer, T.J. and Brown, R.G. and Sidle, K.C.L. and Oliver, D.J. and Allen, C. and Karlsson, J. and Ellis, C.M. and Shaw, C.E. and Al-Chalabi, A. and Goldstein, L.H. (2015) Executive dysfunction predicts social cognition impairment in amyotrophic lateral sclerosis. Journal of Neurobiology, 262 (7). pp. 1681-1690. DOI: 10.1007/s00415-015-7761-0

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Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of the motor system with recognised extra-motor and cognitive involvement. This cross-sectional study examined ALS patients� performance on measures requiring social inference, and determined the relationship between such changes and variations in mood, behaviour, personality, empathy and executive function. Fifty-five ALS patients and 49 healthy controls were compared on tasks measuring social cognition and executive function. ALS patients also completed measures examining mood, behaviour and personality. Regression analyses explored the contribution of executive function, mood, behaviour and personality to social cognition scores within the ALS sample. A between-group MANOVA revealed that, the ALS group was impaired relative to controls on two composite scores for social cognition and executive function. Patients also performed worse on individual tests of executive function measuring cognitive flexibility, response inhibition and concept formation, and on individual aspects of social cognition assessing the attribution of emotional and mental states. Regression analyses indicated that ALS-related executive dysfunction was the main predictor of social cognition performance, above and beyond demographic variables, behaviour, mood and personality. On at least some aspects of social cognition, impaired performance in ALS appears to be secondary to executive dysfunction. The profile of cognitive impairment in ALS supports a cognitive continuum between ALS and frontotemporal dementia.

Item Type: Article
Subjects: Research Publications
Departments: College of Health and Behavioural Sciences > School of Psychology
Date Deposited: 09 Sep 2015 02:19
Last Modified: 23 Sep 2015 02:46
ISSN: 0340-5354
URI: http://e.bangor.ac.uk/id/eprint/5313
Identification Number: DOI: 10.1007/s00415-015-7761-0
Publisher: Springer International Publishing
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