Cost-effectiveness of different strategies to manage patients with sciatica

Fitzimmons, D. and Phillips, C.J. and Bennett, H. and Jones, M. and Williams, N. and Lewis, R. and Sutton, A. and Matar, H.E. and Din, N. and Burton, K. and Nafees, S. and Hendry, M. and Rickard, I. and Wilkinson, C. (2014) Cost-effectiveness of different strategies to manage patients with sciatica. Pain, 155 (7). pp. 1318-1327. DOI: 10.1016/j.pain.2014.04.008

Full-text not available from this repository..


The aim of this paper is to estimate the relative cost-effectiveness of treatment regimens for managing patients with sciatica. A deterministic model structure was constructed, based on information from the findings from a systematic review of clinical and cost-effectiveness, published sources of unit costs and expert opinion. The assumption was patients presenting with sciatica would be managed through one of three pathways (primary care, stepped approach, immediate referral to surgery).. Results were expressed as incremental cost per patient with symptoms successfully resolved. Analysis also included incremental cost per utility gained over a 12 month period. One-way sensitivity analyses were used to address uncertainty. The model demonstrated that none of the strategies resulted in 100% success. For initial treatments, the most successful regime in the first pathway was non-opioids, with a probability of success of 0.613. In the second pathway, the most successful strategy was non-opioids, followed by biological agents, followed by epidural/nerve block and disc surgery, with a probability of success of 0.996. Pathway 3 (immediate surgery) was not cost-effective. Sensitivity analyses identified that the use of the highest cost estimates results in a similar overall picture. While the estimates of cost per QALY are higher, the economic model demonstrated that stepped approaches based on initial treatment with non-opioids are likely to represent the most cost-effective regimens for the treatment of sciatica. However, development of alternative economic modelling approaches is required.

Item Type: Article
Subjects: Research Publications
Departments: College of Health and Behavioural Sciences > North Wales Centre for Primary Care Research
Date Deposited: 11 Mar 2015 03:47
Last Modified: 23 Sep 2015 02:56
ISSN: 0304-3959
URI: http://e.bangor.ac.uk/id/eprint/3623
Identification Number: DOI: 10.1016/j.pain.2014.04.008
Publisher: Wolters Kluwer
Administer Item Administer Item

eBangor is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.