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Exercise intensity and duration effects on in vivo immunity.

Diment, B.C. and Fortes, M.B. and Edwards, J.P. and Hanstock, H.G. and Ward, M.D. and Dunstall, H.M. and Friedmann, P.S. and Walsh, N.P. (2014) Exercise intensity and duration effects on in vivo immunity. Medicine & Science in Sports & Exercise, 47 (7). 1390–1398. DOI: 10.1249/MSS.0000000000000562

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Abstract

Purpose: To examine the effects of intensity and duration of exercise stress on induction of in-vivo immunity in humans using experimental contact hypersensitivity (CHS) with the novel antigen Diphenylcyclopropenone (DPCP). Methods: Sixty-four healthy males completed either 30 minutes running at 60% V[spacing dot above]O2peak (30MI); 30 minutes running at 80% V[spacing dot above]O2peak (30HI); 120 minutes running at 60% V[spacing dot above]O2peak (120MI) or seated rest (CON). Twenty-minutes later subjects received a sensitizing dose of DPCP and four-weeks later the strength of immune reactivity was quantified by measuring the cutaneous responses to a low, dose-series challenge with DPCP on the upper inner-arm. Circulating epinephrine, norepinephrine and cortisol were measured pre, post and 1h post-exercise or CON. Next, to better understand whether the decrease in CHS response on 120MI was due to local inflammatory or T-cell mediated processes, in a cross-over design, eleven healthy males performed 120MI and CON and cutaneous responses to a dose-series of the irritant, croton oil (CO) were assessed on the upper inner-arm. Results: Immune induction by DPCP was impaired by 120MI (skin-fold-thickness -67% vs CON; P<0.05). However, immune induction was unaffected by 30MI and 30HI despite elevated circulating catecholamines (30HI vs pre: P<0.01) and greater circulating cortisol post 30HI (vs CON: P<0.01). There was no effect of 120MI on skin irritant responses to CO. Conclusions: Prolonged, moderate-intensity exercise, but not short-lasting high or short-lasting moderate-intensity exercise, decreases the induction of in-vivo immunity. No effect of prolonged, moderate-intensity exercise on the skin's response to irritant challenge points towards a suppression of cell-mediated immunity in the observed decrease in CHS. DPCP provides an attractive tool to assess the effect of exercise on in-vivo immunity.

Item Type: Article
Subjects: Research Publications
Departments: College of Health and Behavioural Sciences > School of Sport, Health and Exercise Sciences
Date Deposited: 24 Jan 2015 03:07
Last Modified: 15 Jan 2016 03:46
ISSN: 0195-9131
Publisher's Statement: This is a non-final version of an article published in final form in Medicine & Science in Sports & Exercise
URI: http://e.bangor.ac.uk/id/eprint/3428
Identification Number: DOI: 10.1249/MSS.0000000000000562
Publisher: American College of Sports Medicine (ACSM)
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