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Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation

Bedson, E. and Bell, D. and Carr, D. and Carter, B. and Hughes, D.A. and Jorgensen, A. and Lewis, H. and Lloyd, K. and McCaddon, A. and Moat, S. and Pink, J. and Pirmohamed, M. and Roberts, S. and Russell, I. and Sylvestre, Y. and Tranter, R. and Whitaker, R. and Wilkinson, C. and Williams, N. (2014) Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation. Health Technology Assessment, 18 (48). DOI: 10.3310/hta18480

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Abstract

Abstract Background Folate deficiency is associated with depression. Despite the biological plausibility of a causal link, the evidence that adding folate enhances antidepressant treatment is weak. Objectives (1) Estimate the clinical effectiveness and cost-effectiveness of folic acid as adjunct to antidepressant medication (ADM). (2) Explore whether baseline folate and homocysteine predict response to treatment. (3) Investigate whether response to treatment depends on genetic polymorphisms related to folate metabolism.

Item Type: Article
Subjects: Research Publications
Departments: College of Health and Behavioural Sciences > Institute of Medical & Social Care Research
Date Deposited: 17 Jan 2015 03:29
Last Modified: 23 Sep 2015 02:56
ISSN: 1366-5278
URI: http://e.bangor.ac.uk/id/eprint/3374
Identification Number: DOI: 10.3310/hta18480
Publisher: NIHR Health Technology Assessment Programme
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