Discovery of lost diversity of paternal horse lineages using ancient DNA

Lippold, S. and Knapp, M. and Kuznetsova, T. and Leonard, J.A. and Benecke, N. and Ludwig, A. and Rasmussen, M. and Cooper, A. and Weinstock, J. and Willerslev, E. and Shapiro, B. and Hofreiter, M. (2011) Discovery of lost diversity of paternal horse lineages using ancient DNA. Nature Communications, 2. p. 450. DOI: 10.1038/ncomms1447

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Modern domestic horses display abundant genetic diversity within female-inherited mitochondrial DNA, but practically no sequence diversity on the male-inherited Y chromosome. Several hypotheses have been proposed to explain this discrepancy, but can only be tested through knowledge of the diversity in both the ancestral (pre-domestication) maternal and paternal lineages. As wild horses are practically extinct, ancient DNA studies offer the only means to assess this ancestral diversity. Here we show considerable ancestral diversity in ancient male horses by sequencing 4�kb of Y chromosomal DNA from eight ancient wild horses and one 2,800-year-old domesticated horse. Both ancient and modern domestic horses form a separate branch from the ancient wild horses, with the Przewalski horse at its base. Our methodology establishes the feasibility of re-sequencing long ancient nuclear DNA fragments and demonstrates the power of ancient Y chromosome DNA sequence data to provide insights into the evolutionary history of populations.

Item Type: Article
Subjects: Research Publications
Departments: College of Natural Sciences > School of Biological Sciences
Date Deposited: 09 Dec 2014 17:01
Last Modified: 23 Sep 2015 03:20
ISSN: 2041-1723
URI: http://e.bangor.ac.uk/id/eprint/1807
Identification Number: DOI: 10.1038/ncomms1447
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