eBangor

On the ancestral recruitment of metalloproteinases into the venom of snakes

Casewell, N.R. (2012) On the ancestral recruitment of metalloproteinases into the venom of snakes. Toxicon, 60 ((4)). pp. 449-454. DOI: 10.1016/j.toxicon.2012.02.006

Full text not available from this repository.

Abstract

Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin-1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors reveals progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time.

Item Type: Article
Subjects: Research Publications
Date Deposited: 09 Dec 2014 16:49
Last Modified: 23 Sep 2015 03:11
ISSN: 0041-0101
URI: http://e.bangor.ac.uk/id/eprint/1185
Identification Number: DOI: 10.1016/j.toxicon.2012.02.006
Administer Item Administer Item

eBangor is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.